Dr. Kiran Mysore

Submitted by gina on Fri, 2011-06-10 22:06
EPSCoR Research Focus: 
Feedstock Development
Professor
Plant Biology Division
The Samuel Roberts Noble Foundation
http://www.youtube.com/watch?v=mii3giHSUHg&feature=plcp
ksmysore@noble.org
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Education: 
B.S. | Agriculture | Univ. of Agricultural Science, Bangalore, India | 1991
M.S. | Horticulture | Clemson University | 1994
Ph.D. | Genetics | Purdue University | 1999
Post-doc | Plant Genomics | Cornell University | 1999-02
Research Interests: 

Growing a More Disease-Resistant or Disease-Tolerant Switchgrass Plant for Bioenergy Use

Dr. Kiran Mysore's primary areas of research are molecular plant-microbe interactions and plant genomics. One of the main projects in the Mysore laboratory focuses on understanding the non-host pathogen resistance mechanism in plants.

Non-host resistance has been a topic of interest for many plant pathology researchers for several years. So far, very little research has been done to understand the phenomenon of non-host resistance. Dr. Mysore and his co-researchers are using Nicotiana benthamiana and Arabidopsis thaliana as model plants to understand non-host pathogen resistance. Several functional genomic approaches like virus-induced gene silencing (VIGS) and gene expression profiling are being used in these projects.

By identifying the signal transduction components of non-host resistance scientists can better understand how plants defend against pathogens. In future, this will aid researchers in producing a genetically engineer crop plants for broad resistance to several pathogens.

By working to bridge the gap between classical breeding techniques and modern molecular genetics, the EPSCoR research team is optimistic that they may ultimately achieve unprecedented success in biomass feedstock improvement that will significantly enhance Biofuels productivity and lower overall energy costs.

Photo credit: OSU Agriculture Communications

Key Publications: 

Bold items indicate OK EPSCoR-supported research

  • Tadege M., H. Lin, M. Bedair, A. Berbel, J. Wen, C. M. Rojas, L. Niu, Y. Tang, L.1 Sumner, P. Ratet, N. A. McHale, F. Madueño, and K. S. Mysore. “STENOFOLIA Regulates Blade Outgrowth and Leaf Vascular Patterning in Medicago truncatula and Nicotiana sylvestris.” Plant Cell. (2011). doi: 10.1105/tpc.111.085340.
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  • Cheng, X., J. Wen, M. Tadege, P. Ratet, and K. S. Mysore. “Reverse Genetics in Medicago truncatula Using Tnt1 Insertion Mutants.” Methods in Molecular Biology. (2011). 678: 179-90. Springer link. doi: 10.1007/978-1-60761-682-5_13. 
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  • Horváth, M., L. H. Yeun, A. Domonkos, G. Halász, E. Gobbato, F. Ayaydin, K. Míró, S. Hirsch, J. Sun, M. Tadege, P. Ratet, K. S. Mysore, J-M. Ané, G. E. D. Oldroyd, and P. Kaló. “Medicago truncatula IPD3 is a Member of the Common Symbiotic Signaling Pathway Required for Rhizobial and Mycorrhizal Symbioses.” Molecular Plant-Microbe Interactions. (2011). doi: 10.1094/MPMI-01-11-0015.
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  • Laurie, R. E., P. Diwadkar, M. Jaudal, L. Zhang, V. Hecht, J. Wen, M. Tadege, K. S. Mysore, J. Putterill, J. L. Weller, and R. C. Macknight. “The Medicago truncatula FLOWERING LOCUS T Homologue, MtFTa1, is a Key Regulator of Flowering Time.”(2011). doi:10.1104/pp.111.180182.
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  • Murray, J. D., R. R. Duvvuru Muni, I. Torres-Jerez, Y. Tang, S. Allen, M. Andriankaja, G. Li, A. Laxmi, X. Cheng, J. Wen, D. Vaughan, M. Schultze, J. Sun, M. Charpentier, G. Oldroyd, M. Tadege, P. Ratet, K. S. Mysore, R. Chen, and M. K. Udvardi. “Vapyrin, a Gene Essential for Intracellular Progression of Arbuscular Mycorrhizal Symbiosis, is Also Essential for Infection by Rhizobia in the Nodule Symbiosis of Medicago truncatula.” Plant Journal. (2011). 65: 244-252. Wiley Online Library. doi:10.1111/j.1365-313X.2010.04415.x.
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  • Senthil-Kumar, M. and K. S. Mysore. “Caveat of RNAi in Plants: the Off-Target Effect.” Methods in Molecular Biology. (2011). 744: 13-25. Springer Link. doi: 10.1007/978-1-61779-123-9_2.
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  • Senthil-Kumar, M., and K. S. Mysore. "Virus-Induced Gene Silencing Can Persist for More Than 2 Years and Also be Transmitted to Progeny Seedlings in Nicotiana benthamiana and Tomato.” Plant Biotechnology Journal. (2011). Wiley Online Library. doi: 10.1111/j.1467-7652.2011.00589.x.
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  • Uppalapati, S. R., Y. Ishiga, T. Ishiga, and K. S. Mysore. “Involvement of SGT1 in COR-Mediated Signal Transduction Pathway Leading to Disease Symptom Development.” Plant Signaling & Behavior. (2011). 6: 1072-1073. Landes BioScience.
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  • Uppalapati, S. R., Y. Ishiga, C-M. Ryu, T. Ishiga, K. Wang, L. D. Noël, E. J. Parker, and K. S. Mysore. "SGT1 Contributes to Coronatine Signaling and Pseudomonas Syringae Pv. Tomato Disease Symptom Development in Tomato and Arabidopsis." New Phytologist. (2011). 189.1: 83-93. Wiley Online Library. doi:10.1111/j.1469-8137.2010.03470.x.
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  • Vaghchhipawala, Z., C. M. Rojas, M. Senthil-Kumar, and K. S. Mysore. “Agroinoculation and Agroinfiltration: Simple Tools for Complex Gene Function Analyses.” Methods in Molecular Biology. (2011). 678: 65-76. Springer Link. doi: 10.1007/978-1-60761-682-5_6.
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  • Cheng, X., J. Wen, M. Tadege, P. Ratet, and K. S. Mysore. “Reverse Genetics in Medicago truncatula Using Tnt1 Insertion Mutants.” Methods in Molecular Biology. (2011). 678: 179-90. Springer link. doi: 10.1007/978-1-60761-682-5_13. 
  • Horváth, M., L. H. Yeun, A. Domonkos, G. Halász, E. Gobbato, F. Ayaydin, K. Míró, S. Hirsch, J. Sun, M. Tadege, P. Ratet, K. S. Mysore, J-M. Ané, G. E. D. Oldroyd, and P. Kaló. “Medicago truncatula IPD3 is a Member of the Common Symbiotic Signaling Pathway Required for Rhizobial and Mycorrhizal Symbioses.” Molecular Plant-Microbe Interactions. (2011). doi: 10.1094/MPMI-01-11-0015.

  • Laurie, R. E., P. Diwadkar, M. Jaudal, L. Zhang, V. Hecht, J. Wen, M. Tadege, K. S. Mysore, J. Putterill, J. L. Weller, and R. C. Macknight. “The Medicago truncatula FLOWERING LOCUS T Homologue, MtFTa1, is a Key Regulator of Flowering Time.” Plant Physiology. (2011). doi:10.1104/pp.111.180182.
  • Murray, J. D., R. R. Duvvuru Muni, I. Torres-Jerez, Y. Tang, S. Allen, M. Andriankaja, G. Li, A. Laxmi, X. Cheng, J. Wen, D. Vaughan, M. Schultze, J. Sun, M. Charpentier, G. Oldroyd, M. Tadege, P. Ratet, K. S. Mysore, R. Chen, and M. K. Udvardi. “Vapyrin, a Gene Essential for Intracellular Progression of Arbuscular Mycorrhizal Symbiosis, is Also Essential for Infection by Rhizobia in the Nodule Symbiosis of Medicago truncatula.” Plant Journal. (2011). 65: 244-252. Wiley Online Library. doi:10.1111/j.1365-313X.2010.04415.x.

  • Senthil-Kumar, M. and K. S. Mysore. “Caveat of RNAi in Plants: the Off-Target Effect.” Methods in Molecular Biology. (2011). 744: 13-25. Springer Link. doi: 10.1007/978-1-61779-123-9_2.

  • Senthil-Kumar, M., and K. S. Mysore. "Virus-Induced Gene Silencing Can Persist for More Than 2 Years and Also be Transmitted to Progeny Seedlings in Nicotiana benthamiana and Tomato.” Plant Biotechnology Journal. (2011). Wiley Online Library. doi: 10.1111/j.1467-7652.2011.00589.x.
  • Uppalapati, S. R., Y. Ishiga, T. Ishiga, and K. S. Mysore. “Involvement of SGT1 in COR-Mediated Signal Transduction Pathway Leading to Disease Symptom Development.” Plant Signaling & Behavior. (2011). 6: 1072-1073. Landes BioScience.

  • Uppalapati, S. R., Y. Ishiga, V. Doraiswamy, M. Bedair, J. Chen, J. Nakashima, M. Tadege, P. Ratet, R. Chen, H. Schultheiss, and K. S. Mysore. "Irg1 Is a Novel Leaf Epicuticular Wax Mutant of Medicago Truncatula That Confers Enhanced Basal and Nonhost Resistance Against Biotrophic Fungal Pathogens." (2011).

  • Uppalapati, S. R., Y. Ishiga, C-M. Ryu, T. Ishiga, K. Wang, L. D. Noël, E. J. Parker, and K. S. Mysore. "SGT1 Contributes to Coronatine Signaling and Pseudomonas Syringae Pv. Tomato Disease Symptom Development in Tomato and Arabidopsis." New Phytologist. (2011). 189.1: 83-93. Wiley Online Library. doi:10.1111/j.1469-8137.2010.03470.x.

  • Vaghchhipawala, Z., C. M. Rojas, M. Senthil-Kumar, and K. S. Mysore. “Agroinoculation and Agroinfiltration: Simple Tools for Complex Gene Function Analyses.” Methods in Molecular Biology. (2011). 678: 65-76. Springer Link. doi: 10.1007/978-1-60761-682-5_6.

  • Zhou C., L. Han, C. Hou, A. Metelli, L. Qi, M. Tadege, K. S. Mysore, and Z. Y. Wang. “Developmental Analyses of a Medicago Truncatula Mutant Smooth Leaf Margin1 Reveal Distinct Ontogenies Among Plant Organs.” Plant Cell. (2011). doi:10.1105/tpc.111.085464.
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  • Chen J., J. Yu, L. Ge, H. Wang, A. Berbel, Y. Liu, Y. Chen, G. Li, M. Tadege M, J. Wen, V. Cosson, K. S. Mysore, P. Ratet, F. Madueño, G. Bai, and R. Chen. “Control of Dissected Leaf Morphology by a Cys(2)His(2) Zinc Finger Transcription Factor in the Model Legume Medicago truncatula.” Proceedings of the National Academy of Sciences U. S. A. (2010). 107: 10754-10759.
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  • Senthil-Kumar M. and K. S. Mysore. “Assessing Functional Role of Three Water Deficit Stress-Induced Genes in Nonhost Disease Resistance Using Virus-Induced Gene Silencing in Nicotiana benthamiana.” Plant Signaling & Behavior. (2010). 5: 586-590. Landes BioScience. doi: 10.1016/j.plaphy.2009.09.005.
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  • Senthil-Kumar, M., M. Udayakumar, and K. S. Mysore. “Functional Characterization of Water Deficit Stress-Induced Genes using RNAi.” Methods in Molecular Biology. (2010). 639: 193-206.

  • Senthil-Kumar M., R. Hema, T. R. Suryachandra, H. V. Ramegowda, R. Gopalakrishna, N. Rama, M. Udayakumar, and K. S. Mysore. “Functional Characterization of Three Water Deficit Stress-Induced Genes in Tobacco and Arabidopsis: an Approach Based Gene Down Regulation.” Plant Physiology and Biochemistry. (2010). 48(1): 35-44. doi:10.1016/j.plaphy.2010.06.007.

  • Uppalapati, S. R., C. A. Young, S. M. Marek, and K. S. Mysore. “Phymatotrichum (Cotton) Root Rot Caused by Phymatotrichopsis omnivora: Retrospects and Prospects.” Molecular Plant Pathology. (2010). 11: 325-334. doi:10.1111/j.1364-3703.2010.00616.
  • Wang, K., S. R. Uppalapati, X. Zhu, S. P. Dinesh-Kumar, and K. S. Mysore. “SGT1 Positively Regulates the Process of Plant Cell Death During Both Compatible and Incompatible Plant-Pathogen Interactions.” Molecular Plant Pathology. (2010). 11: 597-611. doi:10.1111/j.1364-3703.2010.00631.

  • Wangdi, T., S. R. Uppalapati, C. M. Ryu, C. L. Bender, and K. S. Mysore. “A Role for Chloroplast-Localized Thylakoid formation 1 (THF1) in Bacterial Speck Disease Development.” Plant Signaling & Behavior. (2010). 5: 425-427. PubMed Central.
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  • Wangdi, T., S. R. Uppalapati, C. M. Ryu, C. L. Bender, and K. S. Mysore. “A Virus-Induced Gene Silencing Screen Identifies a Role for Thylakoid Formation1 in Pseudomonas syrinage pv. Tomato Induced Disease Symptom Development in Tomato and Arabidopsis.” Plant Physiology. (2010). 152: 281-292.
  • Uppalapati, S. R., C. A. Young, S. M. Marek, and K. S. Mysore. “Phymatotrichum (Cotton) Root Rot Caused by Phymatotrichopsis omnivora: Retrospects and Prospects.” Molecular Plant Pathology. (2010). 11: 325-334. doi:10.1111/j.1364-3703.2010.00616.
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  • Wang, K., S. R. Uppalapati, X. Zhu, S. P. Dinesh-Kumar, and K. S. Mysore. “SGT1 Positively Regulates the Process of Plant Cell Death During Both Compatible and Incompatible Plant-Pathogen Interactions.” Molecular Plant Pathology. (2010). 11: 597-611. doi:10.1111/j.1364-3703.2010.00631.
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  • Kim, S-C., L. Kang, S. Nagaraj, E. Blancaflor, K. S. Mysore,* and K. Chapman.* “Mutations in Arabidopsis Fatty Acid Amide Hydrolase Reveal that Catalytic Activity Influences Growth but Not Sensitivity to Abscisic Acid or Pathogens.” Journal of Biological Chemistry. (2009). 284(49):34065-34074. (*co-corresponding authors).  doi: 10.1074/jbc.M109.059022.
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  • Kwak, Y., D-W. Bae, K. S. Mysore, and H-K. Kim. “Different Oxidative Burst Patterns Occur During Host and Nonhost Resistance Responses Triggered by Xanthomonas campestris in Pepper.” Journal of Plant Biotechnology. (2009). 36: 244-254. ISSN: 1598-6365.
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  • Pang, Y., J. P. Wenger, K. Saathoff, G. J. Peel, J. Wen, D. Huhman, S. N. Allen, Y. Tang, X. Cheng, M. Tadege, P. Ratet, K. S. Mysore, L. W. Sumner, D. Marks, and R. A. Dixon. “A WD40 Repeat Protein from Medicago truncatula is Necessary for Tissue-Specific Anthocyanin and Proanthocyanidin Biosynthesis, But Not for Trichome Development.” Plant Physiology. (2009). 151(3): 1114-29. doi: 10.1104/pp.109.144022.
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  • Tadege, M., T. L. Wang, J. Wen, P. Ratet, and K. S. Mysore. "Mutagenesis and Beyond! Tools for Understanding Legume Biology." Plant Physiology. (2009). 151: 978-84. Plant Physiology. doi: 10.1104/pp.109.144097.
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  • Uppalapati, S. R., S. M. Marek, H-K. Lee, J. Nakashima, Y. Tang, M. K. Sledge, R. A. Dixon, and K. S. Mysore. “Global Gene Expression Profiling during Medicago truncatula-Phymatotrichopsis omnivora Interaction Reveals a Role for Jasmonic Acid, Ethylene and the Flavonoid Pathway in Disease Development.” Molecular Plant-Microbe Interactions. (2009). 22: 7-17. (Cover page and spotlight article). doi:10.1094/MPMI -22-1-0007.
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  • Anand, A., S. R. Uppalapati, C. M. Ryu, S. Allen, L. Kang, Y. Tang, and K. S. Mysore. "Salicylic Acid and Systemic Acquired Resistance Play a Role in Attenuating Crown Gall Disease Caused by Agrobacterium tumefaciens.” Plant Physiology. (2008). 146: 703-715. doi: 10.1104/pp.107.111302.
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  • Kang, L., Y-S. Wang, S. R. Uppalapati, K. Wang, Y. Tang, V. Vadapalli, B. J. Venables,  K. D. Chapman, E. B. Blancaflor, and K. S. Mysore. “Overexpression of a Fatty Acid Amide Hydrolase Compromises Innate Immunity in Arabidopsis.” Plant Journal. (2008). 56: 336-349. Wiley Online Library. doi: 10.1111/j.1365-313X.2008.03603.x.
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  • Senthil-Kumar, M., A. Anand, S. R. Uppalapati, and K. S. Mysore. “Virus-Induced Gene Silencing and Its Applications.” CAB Reviews: Perspectives in Agriculture, Veterinary Science, Nutrition and Natural Resources. (2008). 3: No. 011. doi: 10.1079/PAVSNNR20083011.
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  • Senthil-Kumar, M., H. V. R. Gowda, R. Hema, K. S. Mysore, and M. Udayakumar. “Virus-Induced Gene Silencing and Its Application in Characterizing Genes Involved in Abiotic Stress Tolerance.” Journal of Plant Physiology. (2008). 165: 1404-1421. 

  • Tadege M., J. Wen, J. He, H. Tu, Y. Kwak, H. Tu, A. Eschstruth, G. Endre, P. Zhao, M. Chabaud, P. Ratet, and K. S. Mysore. “Large Scale Insertional Mutagenesis Using the Tnt1 Retrotransposon in the Model Legume Medicago truncatula.” Plant Journal. (2008). 54: 335-347. doi: 10.1111/j.1365-313X.2008.03418.x.
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  • Uppalapati, S. R., Y. Ishiga, T. Wangdi, E. Urbanczyk-Wochniak, T. Ishiga, K. S. Mysore, and C. L. Bender. “Pathogenicity of Pseudomonas syringae pv. Tomato on Tomato Seedlings: Phenotypic and Gene Expression Analyses of the Virulence Function of Coronatine.” Molecular Plant-Microbe Interactions. (2008). 21: 383-395. doi:10.1094/MPMI -21-4-0383.
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  • Vaghchhipawala, Z., and K. S. Mysore. “Agroinoculation: A Simple Procedure for Systemic Infection of Plants with Viruses.” Methods in Molecular Biology. (2008). 451: 555-562. doi: 10.1007/978-1-59745-102-4_38.
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  • Wang, H., J. Chen, J. Wen, M. Tadege, G., Li, Y. Liu, K. S. Mysore, P. Ratet, and R. Chen. “Control of Compound Leaf Development by FLO/LFY Ortholog Single Leaflet1 (SGL1) in Medicago truncatula.” Plant Physiology. (2008). 146: 1759-1772. doi: 10.1104/pp.108.117044.
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  • Anand, A., Z. Vaghchhipawala, C. Ryu, L. Kang, K. Wang, O. del-Pozo, G. B. Martin, and K. S. Mysore. “Identification and Characterization of Genes Involved in Agrobacterium-Mediated plant Transformation by Virus-Induced Gene Silencing.” Molecular Plant-Microbe Interactions. (2007). 20: 41-52.

  • Anand, A., A. Krichevsky, S. Schornack, T. Lahaye, T. Tzfira, Y. Tang, V. Citovsky, and K. S. Mysore. “VIP2- a VirE2 Interacting Protein is Required for Agrobacterium T-DNA Integration in Plants.” Plant Cell. (2007). 19: 1695-1708.

  • Kilaru, A., E. B. Blancaflor, B. J. Venables, S. Tripathy, K. S. Mysore, and K. D. Chapman. “The N-Acylethanolamine-Mediated Regulatory Pathway in Plants.” Chemistry and Biodiversity. (2007). 4: 1933-1955. Wiley Online Library. doi: 10.1002/cbdv.200790161.
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  • Lei, Z., A. Anand, K. S. Mysore, and L. W. Sumner. “Electroelution of Intact Proteins from SDS-PAGE Gels and Their Subsequent MALDI-TOF MS Analysis.” Methods in Molecular Biology. (2007). 355: 353-364. Springer Link. doi: 10.1385/1-59745-227-0:353.
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  • Senthil-Kumar, M., G. Govind, L. Kang, K. S. Mysore, and M. Udayakumar. “Functional Characterization of Nicotiana benthamiana Homologs of Peanut Water Deficit-Induced Genes by Virus-Induced Gene Silencing.” Planta. (2007). 225(3): 523-39. Springer Link. doi: 10.1007/s00425-006-0367-0.
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  • Senthil-Kumar, M., R. Hema, A. Anand, L. Kang, M. Udayakumar, and K. S. Mysore. "A Systematic Study to Determine the Extent of Gene Silencing in Nicotiana benthamiana and Other Solanaceae Species When Heterologous Gene Sequences are Used for Virus-Induced Gene Silencing.” New Phytologist. (2007). 176: 882-791. Wiley Online Library. doi: 10.1111/j.1469-8137.2007.02225.x.
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  • Uppalapati, S. R., Y. Ishiga, A. Anand, T. Wangdi, B. Kunkel, K. S. Mysore, and C. L. Bender. "The Phytotoxin Coronatine Contributes to Pathogen Fitness and is Required for Suppression of Salicylic Acid Accumulation in Tomato Inoculated with Pseudomonas syringae pv. Tomato DC3000.” Molecular Plant-Microbe Interactions. (2007). 20: 955-965. APS Journals. doi: 10.1094/MPMI-20-8-0955.
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  • Wang, K., L. Kang, A. Anand, and K. S. Mysore. “Monitoring in planta Bacterial Infection and Population at Both Cellular and Whole Plant Levels Using GFPuv.” New Phytologist. (2007). 174: 212-223. (Cover page article).

  • Hwang, H., K. S. Mysore, and S. B. Gelvin. “Transgenic Arabidopsis Plants Expressing Agrobacterium tumefaciens VirD2 Protein are Less Susceptible to Agrobacterium Transformation.” Molecular Plant Pathology. (2006). 7: 473-484. Wiley Online Library. doi: 10.1111/j.1364-3703.2006.00353.x.
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  • Xu, P., Y. Zhang, L. Kang, M. J. Roossinck, and K. S. Mysore. “Computational Estimation and Experimental Verification of Off-Target Silencing During Post-Transcriptional Gene Silencing in Plants.” Plant Physiology. (2006). 142: 429-440.

  • Tadege M., P. Ratet, and K. S. Mysore. “Insertional Mutagenesis: a Swiss Army Knife for Functional Genomics of Medicago truncatula.” Trends in Plant Science. (2005). 10: 229-235.
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  • Tadege M., P. Ratet, and K. S. Mysore. “Insertional Mutagenesis: a Swiss Army Knife for Functional Genomics of Medicago truncatula.” Trends in Plant Science. (2005). 10: 229-235.
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Video Links: 
EPSCoR Bioenergy Project YouTube Video: Kiran Mysore
EPSCoR Bioenergy Research Video
Curriculum Vitae: 
application/pdf iconMysore, Kiran.pdf
Related Links: 
The Samuel Roberts Noble Foundation